Marilyn Lampe, PhD | Elance
 
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Last Sign-in: Nov 13, 2013

Marilyn Lampe, PhD

Expert scientific researcher and writer
   United States
  |   Concord, MA

Resume/C.V.

I provide contract services to pharmaceutical, biotechnology and related firms. Services provided include grant preparation, literature surveys, and pre-publication reviews and proof reading.

I excel at literature searches, as well as written and verbal communication.

My work history includes:

Post doctoral Fellow, Department of Immunopatholgy
Dana Farber Cancer Institute

1989 – 1993 (3 years) Boston, MA


Post doctoral fellow, Virology Department
University of California

1987 – 1988 (1 year) Greater Los Angeles Area


Research Assistant
Veterans Health Administration
Government Agency; 10,001+ employees; Hospital & Health Care industry
1979 – 1982 (3 years) San Francisco Bay Area


Research Assistant
Kalama Chemical Company

1979 – 1979 (less than a year)
Service Description
I will provide literature searches to provide new material or supporting materials as needed by the client.

i can provide paragraphs, articles, blogs written in either a very scientific style ( as suited to a peer review journal) or a more conversational style that can be understood by anyone, as the client desires.

My work is extremely well researched and written. any work will be done within the guidelines set by the client and well within the time frame set by the client.

My previous experience is in the academic world, so my written work has been published. this is a sample


PUBLICATIONS
Human stratum corneum lipids: characterization and regional variations.
Journal of Lipid Research1983
Authors: Marilyn Lampe, B.A.
The lipids of mammalian stratum corneum are known to be important regulators of skin permeability. Since the human stratum corneum displays remarkable regional variations in skin permeability, we assessed the total lipid concentration, the distribution of all major lipid species, and the fatty acid composition in Bligh-Dyer extracts from four skin sites (abdomen, leg, face, and sole) that are...more

Human epidermal lipids: characterization and modulations during differentiation
Journal of Lipid Research1983
Authors: Marilyn Lampe, B.A.
Using thin-layer chromatography and glass capillary gas-liquid chromatography, we have quantitated the lipids in the germinative, differentiating, and fully cornified layers in human epidermis. As previously noted in nonhuman species, we found progressive depletion of phospholipids coupled with repletion of sterols and sphingolipids during differentiation. The sphingolipids, present only in small...more

Diazacholesterol-induced ichthyosis in the hairless mouse. I. Morphologic, histochemical, and lipid biochemical characterization of a new animal model.
Laboratory Investigatons1983
Authors: Marilyn Lampe, B.A.
Several drugs that interfere with sterol metabolism have been associated with hyperkeratosis in man. We found that 20,25-diazacholesterol (30 to 60 mg/kg/day), administered to hairless mice that were otherwise given normal laboratory chow and water ad libitum, consistently produced ichthyosis after 6 to 9 weeks, an effect that was reversible with removal of drug or with coadministration of a high...more

Small Angle X-Ray diffraction Patterns of Stratum Corneum and a Model Structure for Its Lipids
Journal of Dispersion Science and Technology1985
Authors: Marilyn Lampe, B.A.
The structure of the lipid part of stratum corneum,was shown to be a lamellar liquid crystal in accordance with earlier suagestions by Elias et al.

The main structure forming compound was found to be the fatly acids which when partially neutralized gave a lamellar liquid crystal over a wide range of water content.

Small angle x-ray diffraction was used to estimate the location of the...more

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and sterol synthesis by cholesterol sulfate in cultured fibroblasts
Molecular Cell Research1985
Authors: Marilyn Lampe, B.A.
Although widely distributed throughout mammalian tissues, the biological function of cholesterol sulfate remains largely unknown. In these studies we have demonstrated that cholesterol sulfate suppresses de novo sterol synthesis in cultured human fibroblasts. It was further shown in these cultured cells that cholesterol sulfate is a potent inhibitor of the enzyme, 3-hydroxy-3-methylglutaryl...more


Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster Edit
Xenobiotica1990
Authors: Marilyn Lampe, Ph.D
1. The metabolism of methapyrilene (MPH) by rat, hamster and mouse liver microsomes in vitro was investigated together with the binding of 14C-MPH to calf thymus DNA after metabolic activation.

2. Both quantitative and qualitative differences in MPH metabolism were observed in these three species. Mouse liver microsomes catalyse the formation of two novel isomers of hydroxypyridylmethapyrilene...more

Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro
Oxford University Press1987
Authors: Marilyn Lampe, Ph.D
Methapyrilene ([14C]MHP) was found to bind to calf thymus DNA only after activation by both rat liver microsomes and NADPH. The cytochrome P-450 inhibitors 2,4-dichloro-6-phenylphenoxyethylamine, 2-diethylaminoethyl-2,2-diphenyl-valerate and metyrapone inhibited binding, but methimazole, a flavin-dependent monooxygenase inhibitor, had no effect. However, 1,2-epoxy-3,3,3-trichloropropane,

Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease.
The Journal of Immunology1991
Authors: Marilyn Lampe, Ph.D
Studies of systemic autoimmune disease have led to the view that initiation and progression of the disease process reflects chronic and sustained B cell activation by unidentified polyclonal activating agents. In earlier studies, we found that T cells from MRL/1 mice, which develop murine lupus, express very high levels of a newly defined T cell cytokine, Eta-1. Inasmuch as chronic and sustained B….
Education
university of California, Los Angeles
Doctorate
-
Reed College, Portland, OR
Bachelor of Atrs
-
Payment Terms
Payment terms vary depending on the Elance client.
Marilyn Lampe, PhD | Elance

Marilyn Lampe, PhD